p53 regulates diverse tissue-specific outcomes to endogenous
WEBMar 21, 2024 · We find that p53, a central regulator of the cellular response to DNA damage, regulates tissue dysfunction in Ercc1-/- mice in different ways. We show that ablation of p53 rescues the loss of...
Trp53 transformation related protein 53 [ (house mouse)]
WEBSep 10, 2024 · p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice. p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6. p53 promotes antiviral innate immunity by driving hexosamine metabolism.
p53: A tale of complexity and context - Cell Press
WEBMar 28, 2024 · Researchers eagerly sought to use cells from these mice to test their ideas about how p53 might work, and one of the first important observations was that cells from p53-null mice are genomically more unstable than their WT counterparts. Key findings emanating from p53-null mice did not stop there.
Mouse Models of p53 Functions - PMC - National Center for …
WEBMouse models with activated p53, no p53, and mutant p53 have queried the role of p53 in development and tumorigenesis. In these models, p53 is activated and stabilized via redundant posttranslational modifications.
20 years studying p53 functions in genetically engineered mice
WEBSep 24, 2009 · As expected, mice that have mutant Trp53 alleles usually develop cancers of various types more rapidly than their counterparts that have wild-type Trp53 genes. These mouse studies have been...
The p53-deficient mouse: a model for basic and applied cancer ... - PubMed
WEBThe p53-deficient mice have been particularly valuable in examining the effects of p53 loss on tumor progression. In addition, the mice hold significant promise as tools to assess carcinogens, teratogens, chemopreventative agents, and cancer therapeutic regimens.
The multiple mechanisms that regulate p53 activity and cell fate
WEBMar 1, 2019 · The tumour suppressor p53 has a central role in the response to cellular stress. Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes,...
Mice Are Not Humans: The Case of p53 - Cell Press
WEBSep 17, 2020 · Recent studies have revealed that GRNs of the well-studied p53 transcription factor family members p53 and p63 differ substantially between mouse and human [7,8]. Given that p63 (ΔNp63) serves a crucial role in squamous cell carcinoma development and p53 is key to the development of almost all tumors, the extensive difference in their GRNs ...
Endogenous p53 expression in human and mouse is not …
WEBMay 6, 2021 · Using these tools, we conclude that the endogenous TP53 3′UTR does not have a significant impact on p53 abundance regulation under standard conditions used to study p53, including induction of DNA damage in HCT116 cells and total body irradiation of mice (Figures 1D, 2B, D, H, 5B and D).
Understanding the complexity of p53 in a new era of tumor …
WEBMay 9, 2024 · p53 plays a central role in suppressing tumorigenesis. In this issue, Liu et al. review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that largely expand the scope of its anti-tumor activity.