Allometrically scaling tissue forces drive pathological foreign-body ...
WEBSep 25, 2023 · Comparative analysis of histology sections of FBR capsules from the MSI mouse model either pharmacologically blocked with Rac inhibitor (RI) or genetically blocked in a Rac2 −/− global KO...
Rho-Family Small GTPases: From Highly Polarized Sensory …
WEBJan 28, 2019 · Knockout (KO) mice availability, congenital diseases, and tumorigenesis-associated Rho-family GTPases. Blue indicates typical (classical) Rho-family GTPases including the Rho, Rac, Cdc42, and RhoD/RhoF subfamilies.
Mammalian Rho GTPases: new insights into their functions from
WEBKnockout mice for five Rho GTPases — RhoB, RhoC, RAC2, RAC3 and RhoH — are viable and fertile, allowing studies of their functions in vivo and in cells purified from tissues.
RAC2 and primary human immune deficiencies - Lougaris - 2020 …
WEBJun 15, 2020 · Mutations in RAC2 have been identified in a small number of patients giving rise to different forms of primary immunodeficiencies ranging from granulocyte defects caused by dominant negative mutations to combined immunodeficiency due to dominant activating mutations.
Opposing roles of hematopoietic-specific small GTPase Rac2 …
WEBApr 27, 2020 · This was demonstrated by higher and lower bone density in the femurs from Rac2-deficient (Rac2−/−) and Vav1-deficient (Vav1−/−) mice, respectively, compared to the wild-type (WT) mice.
Immunobiology: Rac GTPase isoforms Rac1 and Rac2 play a …
WEBSep 1, 2008 · These data suggest that combined effects of Rac1/Rac2 deficiency on T-cell proliferation, survival, adhesion, and migration may contribute to the reduced mature T-cell numbers in the Rac1/Rac2 knockout mice.
Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage …
WEBApr 25, 2014 · Microarray, RT-PCR and metabolomic analysis on bone marrow derived macrophages isolated from the Rac2-/- mice identify an important role for Rac2 in M2 macrophage differentiation.
Hematopoietic-specific Rho GTPases Rac2 and RhoH and human …
WEBSep 10, 2013 · The generation of mouse knock-out lines has led to new understanding of the functions of both of these proteins in blood cells. The phenotype of these mice also led to the identification of mutations in human RAC2 and RHOH genes and the role of these proteins in immunodeficiency diseases.
Rac2 Specificity in Macrophage Integrin Signaling - Journal of ...
WEB7. ). Rac activation results from a combination of reduced association with GDP dissociation inhibitors and/or enhanced exchange of GDP to GTP promoted by guanine nucleotide exchange factors. Activated GTP-bound Rac proteins then transduce signals to down-stream effector proteins.
Human neutrophils coordinate chemotaxis by differential activation …
WEBAug 15, 2009 · We demonstrate distinct activation kinetics and different roles for Rac1 and Rac2 in response to low vs high concentrations of fMLP. These observations were verified using neutrophils from mice in which Rac1 or Rac2 was genetically absent.