Proximal tubular RAGE mediated the renal fibrosis in UUO model mice …
WEBApr 23, 2022 · UUO-induced kidney fibrosis is alleviated in PT-RAGE-KO mice via inhibition of STAT3/Atg7 axis. The PT-RAGE-KO and PT-RAGE-WT littermate mice were subjected to UUO model for 7 days.
Receptor for Advanced Glycation End Products (RAGE): A Pivotal …
WEBAug 2, 2022 · RAGE knockout mice appear to be healthy and develop normally, suggesting that inhibition of RAGE is a safe therapeutic approach. Extensive studies in mice using various RAGE inhibitors, mainly excess sRAGE decoys, showed no deleterious effects of RAGE inhibition.
Knockout of receptor for advanced glycation end‐products …
WEBFeb 22, 2019 · Although the small sample sizes necessitate caution in interpreting our results, we here report that RAGE knockout mice developed significantly less nephrosclerosis and senile amyloid lesions than WT mice, suggesting a key role for this receptor in the renal aging process.
Genetic deficiency of neuronal RAGE protects against AGE …
WEBJun 12, 2014 · Here we analyze the contribution of neuronal receptor of AGEs (RAGE) signaling to AGE-mediated synaptic injury using novel transgenic neuronal RAGE knockout mice specifically targeted to...
All the “RAGE” in lung disease: The receptor for advanced …
WEBIn one study, wild-type and RAGE knockout (KO) mice were treated with house dust mite (HDM) extract. This led to airway eosinophilia, goblet cell hyperplasia, and impaired pulmonary function after methacholine challenge in wild-type mice [ 80 ].
The role of the receptor for advanced glycation end-products …
WEBMar 19, 2010 · RAGE knockout (KO) mice get worse fibrosis when challenged with asbestos, whereas in the bleomycin model they are largely protected against fibrosis. In the current study the role of RAGE in a mouse model of …
Receptor for advanced glycation end-products and child neglect in mice …
WEBAug 1, 2022 · In RAGE KO mice, while hyperactivity has been reported in male mice, maternal behavior was impaired in female mice. After an additional stress, deficits in pup care were observed in RAGE KO mother mice. This resulted in pup death within 1–2 days, suggesting that RAGE plays a critical role during the postpartum period.
The receptor for advanced glycation end products (RAGE) is …
WEBFeb 1, 2023 · Independent of cigarette smoke exposure, RAGE KO decreased mitochondrial specific maximal respiration (P < 0.05), resulting in a compensatory increase in mitochondrial content measured by citrate synthase activity (P < 0.001) such that muscle respiratory capacity remained unaltered.
Receptor for advanced glycation end-products (RAGE) mediates ...
WEBAug 16, 2022 · To determine whether Rage (the mouse homolog) is required for spore internalization in ATII cells, RNA interference (RNAi)-mediated Rage knockdown was performed.
RAGE pathways play an important role in regulation of organ …
WEBJun 15, 2023 · In light of new knowledge, the receptor for advanced glycation end products (RAGE) emerged as an important candidate for the regulation of a wide variety of cellular functions related to fibrosis, including inflammation, cell …
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