The respective contribution of tumour suppressor p53-activated cellular response pathways to prevention of tumour development remains debated. This resource introduces three novel mouse strains for ...

Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or ...

The model is engineered such that pancreatic epithelial cells become Kras G12D, p53-/+ and express mKate (red) and GFP when mice are given doxycycline. Because the GFP cassette is linked to the ...

(c) Body weight changes in the xenograft nude mouse model during the BC treatment period. (d) Representative western blots and quantifications of the P53 level in tumor tissues after BC treatment ...

“A proteosome inhibitor effectively jams the shredder so that p53 is not immediately broken down.” In this study, the research team used a mutant strain of mice in which p53 activity can be sw ...

The major allergen for mouse is Mus m 1 which is predominantly found in the urine. Specific IgE to mouse is determined using either a commercial skin prick test solution of mouse epithelium or ...

Previously the authors have demonstrated that activation of p53 with the specific Mdm2 inhibitor, Nutlin, induces apoptosis in trophoblast cell lines. Our objective was to determine whether Nutlin ...

When tested in mouse models of cancer ... Their specific target was a peptide containing the R175H mutation of p53 (the 175th ...

Athar said that he has not detected any negative side effects of the drug in mice; however, earlier work has suggested that too much p53 can cause premature ageing. CP-31398 restores mutant p53 ...

have discovered that, in mice, Rps27I regulates the p53 protein in two different ways. In normal cells, Rps27l appears to inhibit p53, which is likely to encourage cancer to develop. But, if a cell ...

RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...