This important study using engineered mouse models provides a first and compelling demonstration of a pathogenic phenotype associated with lack of expression of p53AS, an isoform of the p53 protein ...

(c) Body weight changes in the xenograft nude mouse model during the BC treatment period. (d) Representative western blots and quantifications of the P53 level in tumor tissues after BC treatment ...

Despite advances in therapeutic approaches, lung cancer remains the leading cause of cancer-related deaths. To understand the molecular programs underlying lung cancer initiation and maintenance, we ...

We characterized those mice. One of the important things we learned is that the mice that have only one TP53 mutation, or who only have loss of one p53 allele, don't progress to leukemia. We follow ...

ROCKVILLE, Md. and SUZHOU, China, Sept. 13, 2024 /PRNewswire/ — Ascentage Pharma (6855.HK), a global biopharmaceutical ...

A new study from researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) sheds light on ...

Researchers at the University of Michigan Rogel Cancer Center have uncovered a possible way to stop prostate tumors from ...

Journal of Nuclear Medicine September 2024, jnumed.124.267736; DOI: https://doi.org/10.2967/jnumed.124.267736 ...

Nude mice model was used to detect the role of RTN3 in modulating ... RTN3 restrained HCC growth and induced apoptosis by activating p53. Mechanism studies indicated that RTN3 facilitated p53 Ser392 ...

RKIP deficiency protects mice from DSS-induced or TNBS-induced colitis and accelerated ... Mechanistically, RKIP enhances the induction of P53-upregulated modulator of apoptosis by interacting with ...